Nucleotide Excision Repair - NER

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Produced with the support of Inserm and the Institute of Genetics and Molecular and Cellular Biology (IGBMC, Ilkirch), this animated film shows, at the molecular level, how DNA damage is eliminated by one of the DNA repair systems: Nucleotide Excision Repair (NER).

Our genetic heritage - or to be more exact, the DNA making it up - is under constant attack. For too much exposure to the sun’s UV rays, to tobacco smoke and to countless other substances found in our environment can damage our DNA. We talk of "genotoxic stress".

The damage caused is potentially life-threatening as it can alter the way our body’s cells function and cause them to turn into cancer cells. Fortunately, there are cell mechanisms tasked with detecting this damage and getting rid of it. For that, the cell has several DNA repair systems for managing and eliminating the different types of damage that can alter genetic material.

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Produced with the support of Inserm and the Institute of Genetics and Molecular and Cellular Biology (IGBMC, Ilkirch), this animated film shows, at the molecular level, how DNA damage is eliminated by one of the DNA repair systems: Nucleotide Excision Repair (NER).

Directed by Jean-Marc Egly, Christophe Giraudon et Gabriel Picard.

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