Biology of cancer and of infection

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Human endothelial cells infected by Pseudomonas aeruginosa, with a loss of cell-cell junctions (VE-cadherin in violet) and microtubules (green) in the infected zone to the right of the image.

Infection by Pseudomonas aeruginosa

Human endothelial cells infected by Pseudomonas aeruginosa, with a loss of cell-cell junctions (VE-cadherin in violet) and microtubules (green) in the infected zone to the right of the image.

 

Cardiomyocytes of mice infected by Trypanosoma cruzi, the parasitic agent responsible for Chagas' disease. Red coloring: cardiomyocyte actin fibers; Green coloring: marking of intracellular parasites.

Chagas' disease

Cardiomyocytes of mice infected by Trypanosoma cruzi, the parasitic agent responsible for Chagas' disease. Red coloring: cardiomyocyte actin fibers; Green coloring: marking of intracellular parasites.

 

Human endothelial cells are extracted from the umbilical vein and then placed in a culture at 37°C in the presence of CO2. In these conditions, they will multiply until the entire surface of the dish is covered. The cells are then fixed before carrying out fluorescent marking. The color green represents a marking of our protein of interest, VE-cadherin which underlines the junctions between the cells. The nucleus of the cells is shown in blue and red is used to show the actin filaments which maintain the shape of the cells.

Endothelial monolayer

Human endothelial cells are extracted from the umbilical vein and then placed in a culture at 37°C in the presence of CO2. In these conditions, they will multiply until the entire surface of the dish is covered. The cells are then fixed before carrying out fluorescent marking. The color green represents a marking of our protein of interest, VE-cadherin which underlines the junctions between the cells. The nucleus of the cells is shown in blue and red is used to show the actin filaments which maintain the shape of the cells.

 

Protein kinase CK2 - Predictive models showing the interaction of a chemical inhibitor with the catalytic sub-unit of the protein kinase CK2. The inhibitor, identified via virtual screening blocks the interaction between the two sub-units of the kinase.

Protein kinase CK2

Predictive models showing the interaction of a chemical inhibitor with the catalytic sub-unit of the protein kinase CK2. The inhibitor, identified via virtual screening blocks the interaction between the two sub-units of the kinase.

 

Angiogenesis study in mice. Marking of the retina of a mouse (7th day after birth). Blood vessels (in green: isolectin B4). Fluorescent microscopy, magnification x2.5.

Mouse retina

Angiogenesis study in mice. Marking of the retina of a mouse (7th day after birth). Blood vessels (in green: isolectin B4). Fluorescent microscopy, magnification x2.5.

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